Physicochemistry of APIs and dosage forms

The aim is to develop theories on the formation of dispersed systems (emulsions, suspensions, foams, etc.), with emphasis on thermodynamic and physicochemical aspects. An important part of the course is devoted to the knowledge of surfactants, their chemical nature and mode of action, and their use in the formulation and stabilization of dispersions. The essential properties of dispersed systems, such as particle size, rheology, Zeta potential, etc., are described in detail. Thermodynamic and kinetic aspects of dispersion stabilization are also covered, providing a good understanding of the mechanisms involved at interfaces. The physicochemical properties of Active Pharmaceutical Ingredients (APIs) are also presented. The course covers the essential notions for characterizing the main physicochemical properties of bioactive molecules and APIs (e.g. Lipinski's rule of five, Veber's rules).

Theoretical teaching is structured around five lectures:

• Physicochemistry at the heart of drug design.
• Surfactants.
• Suspensions.
• Emulsions.
• Physicochemical properties of APIs.

The lectures are supplemented by several practical sessions focusing on physicochemical issues. Analysis of formulas will enable students to decipher results, compare formulas and interpret them in terms of constituent properties. The critical analysis of articles (LCA) also enables us to discuss the various physicochemical properties of IPAs and the art of optimizing them. The use of prediction tools is also covered.